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In line with the well-documented incompatibility between animal experiments and human trials (209, 307, 308), current evidence from systematic reviews identified significant limitations in preclinical animal research, encompassing both the quality of publications and translational value (209, 210)

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If clinically indicated, as in cases with suboptimal curve improvement, the complete 3Ts protocol may be repeated for an additional 3-month treatment cycle

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the net metabolic effect is under active investigation Retatrutide has been studied as a once-weekly subcutaneous injection in clinical trials